Mounjaro

Mounjaro® injection is a prescription medicine that helps lower blood sugar levels in people with type 2 diabetes and promotes weight loss through its active ingredient, Tirzepatide.

Mounjaro® (Tirzepatide) benefits:

1. Dual Receptor Action:
   • Appetite Reduction: Activates GIP and GLP-1 receptors, effectively reducing hunger.
   • Enhanced Satiety: Delays gastric emptying, increasing feelings of fullness.
2. Weight and Glucose Management:
   • Significant Weight Loss: Promotes notable weight reduction by decreasing food intake and enhancing insulin sensitivity.
   • Blood Sugar Control: Improves glucose regulation by enhancing insulin secretion and reducing glucagon levels.
3. Metabolic Benefits:
   • Improved Insulin Sensitivity: Enhances insulin response to meals.
   • Comprehensive Glucose Management: Lowers both fasting and postprandial glucose levels.

Overall Benefits:

• Convenient Dosing: medication is administered once weekly, making adherence simpler.
• Holistic Approach: by managing both weight and glucose levels, these medications support overall health improvements.
• Supportive of Lifestyle Changes: when combined with diet and exercise, they help achieve better health outcomes.

Application:

Mounjaro comes as a pre-filled pen for subcutaneous injection.

• Take one injection weekly.
• Inject at any time of day, with or without meals.
• Choose the injection site: thigh, abdomen, or upper arm.

Precautions:

1. Who Should Not Use Mounjaro®:
   • History of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
   • Known serious hypersensitivity to tirzepatide or any component of Mounjaro®.
2. Monitoring:
   • Blood Glucose: Particularly important if combined with other glucose-lowering agents.
   • Renal Function: Monitor kidney function, especially if you experience severe gastrointestinal symptoms.
   • Heart Rate: Report any significant increases in heart rate.
3. Interactions:
   • Oral Medications: Mounjaro® may delay gastric emptying, potentially affecting the absorption of oral medications.
   • Contraceptives: Consider switching to a non-oral contraceptive method or add a barrier method of contraception due to potential interactions affecting absorption.

General Precautions:

• Lifestyle Adjustments: Maintain a healthy diet and exercise routine to enhance treatment effectiveness.
• Regular Check-ups: Schedule routine visits with your healthcare provider to monitor your health and medication effects.
• Emergency Contacts: Keep your healthcare provider's contact information handy for any urgent concerns.

Side Effects:

As with all medications, some people experience side effects.

1. Common Side Effects:
   • Nausea
   • Diarrhoea
   • Decreased appetite
   • Vomiting
   • Constipation
2. Uncommon Side Effects:
   • Pancreatitis: Look out for persistent, severe abdominal pain.
   • Hypoglycaemia: Risk increases if combined with insulin or insulin secretagogues.
   • Hypersensitivity Reactions: Possible severe allergic reactions include rash, itching, or swelling.
   • Acute Kidney Injury: Monitor for signs such as decreased urine or fluid retention.
   • Gallbladder Disease: Includes symptoms like sudden pain in the upper right abdomen, nausea, and fever.
   • Heart Rate Increase: Some patients may experience an increase in heart rate.

Important: If you experience any severe or persistent symptoms, contact your healthcare provider immediately. This leaflet does not include all potential side effects. For complete information, refer to the full prescribing information or speak with your healthcare professional.

For detailed information about these medications, including full prescribing information, safety data, and usage instructions, please visit the official manufacturer website Mounjaro (www.mounjaro.com) by Eli Lilly.

Additional regulatory information can be found in the electronic medicines compendium at www.medicines.org.uk .

Ingredients:

Tirzepatide is the active ingredient. The other ingredients are sodium chloride, sodium phosphate, dibasic heptahydrate, and water for injection.